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Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare.

Pathology

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Pathology.

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"La théorie de la dégénérescence attribue l'origine des troubles mentaux à une transmission héréditaire ; elle domine la psychiatrie de la seconde moitié du XIXe siècle. Généralisée ensuite, elle a participé à la naissance d'idéologies eugénistes et racistes et nourri les attaques contre une société industrielle et libérale, jugée dégénérée en raison du mélange de classes et de races, mortel pour la civilisation, qu'elle passait pour favoriser.

Degeneration (Pathology) --- Pathology --- Philosophy.

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Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or nuclear DNA can result in a MRC deficiency. Whilst a single organ can be affected, MRC disorders often result in a multi-organ system presentation with prominent neurological and myopathic features. The diagnosis of MRC disorders can be complex, and requires a coordinated interplay of a number of disciplines. However, biochemical determination of metabolites in blood, cerebral spinal fluid (CSF) and/or urine are generally considered to be first-line investigations for the diagnosis of these disorders, although they lack sensitivity and specificity. Furthermore, there is a lack of consensus on the overall utility of monitoring other biochemical parameters, which may be of diagnostic value. For example, although oxidative stress may contribute to the pathogenesis of mitochondrial disorders, few centers monitor this as part of their diagnostic repertoire. Therefore, the purpose of this Special Issue was to highlight potential biomarkers of mitochondrial disease and to discuss the appropriateness of biochemical markers to monitor disease progression and therapeutic intervention.

Mitochondrial pathology.

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Within the field of pathology, there is a wide gap in pedagogy between medical school and residency. As a result, the pathology intern often comes into residency unprepared for the practical demands of the field, and without the foundation to digest professional-level textbooks. Completely illustrated in color, this book is uniquely directed at the junior pathology resident, and goes first through some very basic introductory material, then progresses through each organ system. Within each chapter, there is a brief review of salient normal histology, a discussion of typical specimen types, a strategic approach to the specimen, and a discussion of how the multitude of different diagnoses relate to each other. The book’s goal is to lay the foundation of practical pathology, and provide a scaffold on which to build more detailed knowledge. The second edition retains the informal voice and brevity of the first edition, but with new and expanded chapters, new illustrations, and updated material.

Pathology --- pathologie